Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis
نویسندگان
چکیده
منابع مشابه
Design, synthesis and antitubercular evaluation of benzothiazinones containing an oximido or amino nitrogen heterocycle moiety
A series of 8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-ones (BTZs) bearing an oximido or amino nitrogen heterocycle moiety through modifications at the C-2 position of BTZ043 and BPTZ169 were designed and synthesized as new antitubercular agents. Many of the target compounds demonstrate excellent in vitro activity (MIC: <0.016–0.088 mg mL ) against the drug susceptive H37Rv strain and two c...
متن کاملSynthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking.
We previously reported 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanoe (LM49), a bromophenol analogue that shows strong protection from oxidative stress injury owing to its superior anti-inflammatory, antioxidant, and anti-apoptotic properties. A series of novel nitrogen-containing heterocycle bromophenols were herein synthesized by introducing substituted piperidine, piperazine, and imidazole ...
متن کاملSynthesis, singlet oxygen photogeneration and DNA photocleavage of porphyrins with nitrogen heterocycle tails.
Eight novel compounds were prepared by reaction of 5-(bromo- propoxyphenyl)-10,15,20-triphenylporphyrin with oxazole thiols, 1,3,4-oxadiazole thiols and 1,3,4-thiadiazole thiols, and their structures confirmed by UV-vis, IR, 1H-NMR, MS and elemental analysis. The assessment of indirectly measured 1O(2) production rates against 5,10,15,20-tetraphenyl porphyrin (H(2)TPP) were described and the re...
متن کاملGlutamine: precursor or nitrogen donor for citrulline synthesis?
Although glutamine is considered the main precursor for citrulline synthesis, the current literature does not differentiate between the contribution of glutamine carbon skeleton vs. nonspecific nitrogen (i.e., ammonia) and carbon derived from glutamine oxidation. To elucidate the role of glutamine and nonspecific nitrogen in the synthesis of citrulline, l-[2-(15)N]- and l-[5-(15)N]glutamine and...
متن کاملSynthesis and Characterization of New Nitrogen Donor Ligands
Five new nitrogen donor ligands have been prepared with the bidentate Schiff bases derived from a 2:1 molar condensation of different types of aldehydes with ethylenediamine. Two new ligands with a 2-hydrazonomethylphenol moiety have also been prepared from a 1:1 molar condensation of the 2-hydrazonomethyl-phenol with an appropriate furaldehyde. The ligands were characterised on the basis of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1230704